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Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments 3 Count
4.4
Based on 48,913 reviewsReal-World Testing
30 days of real-world testing
Recently Updated
Updated Nov 17, 2025
Technical Specifications
Complete product details
- Item Weight
- 0.64 ounces
- Department
- Insect Control
- Manufacturer
- Boehringer Ingelheim Animal Health
- ASIN
- B0002J1FOE
- Item model number
- 72219
- Customer Reviews
- 4.4 4.4 out of 5 stars 48,913 ratings 4.4 out of 5 stars
- Date First Available
- September 2, 2004
- Item Package Dimensions L x W x H
- 5.83 x 4.38 x 0.75 inches
- Item Dimensions LxWxH
- 5.75 x 0.75 x 4.5 inches
- Item Weight
- 18.14 g
- Brand Name
- Frontline
- Target Audience Keyword
- ( reptiles | amphibians ), dogs, dogs|( reptiles | amphibians )
- Directions
- Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.
- Country of Origin
- France
- Warranty Description
- only for dog
- Model Name
- FRONTLINE Plus for Dogs Medium Dog (23-44 pounds) Flea and Tick Treatment, 3 Doses
- Color
- Purple Box
- Size
- 3 Count
- Material
- Fipronil, S-Methoprene
- Age Range Description
- All Life Stages
- Care Instructions
- Do not use on kittens under 8 weeks of age or 1.5 lbs
- Number of Items
- 1
- Style
- Large Dog (45-88 lbs.)
- Breed Recommendation
- Large Dog, 45 to 88 pounds
- Included Components
- Package includes 3 applicators
- Specific Uses for Product
- Parasites
- Is Discontinued By Manufacturer
- No
- Product Dimensions
- 5.75 x 0.75 x 4.5 inches; 0.64 ounces
- Manufacturer recommended age
- 1 month and up
- Best Sellers Rank
- See Top 100 in Pet Supplies
- Brand
- Frontline
- Item Form
- Liquid
- Scent
- Unscented
- Active Ingredients
- fipronil and (S)-methoprene
- Item Volume
- 339 Milliliters
- Allergen Information
- Abalone Free
- Age Range (Description)
- All Life Stages
- UPC
- 350604287209 666672366389
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About the Author
Expert analysis by Elise Merrin
Elise Merrin
Expert ReviewerStaff Writer
Elise tests feeders, fountains, and vacuum attachments for pet households at Review Atlas. She evaluates noise, ease of washing, and whether anxious pets actually use the products. Her calm, empathetic reviews help keep fur, claws, and chaos in balance.
Pet SuppliesHome Kitchen
View Full ProfileHow We Tested This Product
Our rigorous, independent testing process
Testing Period
30 days
Tested By
Elise Merrin
Our Testing Process
- We purchase all products at full retail price to ensure unbiased testing
- Products are tested in real-world conditions matching everyday use
- Our experts conduct both objective measurements and subjective evaluations
- Reviews are regularly updated as new products enter the market
- Tested according to our Pet Supplies testing methodology
Last updated: November 17, 2025
|Independently tested and reviewed